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MRI was perormed in 21 patients and single photon emission computed tomography(SPECT)with N-isopropyl-p-123 I iodoamphetamine in 16 patients, to visualize upper motor neurone lesions in amyotrophic lateral sclerosis. T2-weighted MRI revealed high signal along the course of the pyramidal tract in the internal capsule and cerbral peduncle in 4 of 21 patients. SPECT images were normal in 4 patients,but uptake was reduced in the cerebral cortex that includes the motor area in 11. |
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